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KMID : 0613820130230040595
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Journal of Life Science
2013 Volume.23 No. 4 p.595 ~ p.601
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Investigation of Conserved Genes in Eukaryotes Common to Prokaryotes
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Lee Dong-Geun
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Abstract
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The clusters of orthologous groups of proteins (COG) algorithm was applied to identify essential proteins in eukaryotes and to measure the degree of conservation. Sixty-three orthologous groups, which were conserved in 66 microbial genomes, enlarged to 104 eukaryotic orthologous groups (KOGs) and 71 KOGs were conserved at the nuclear genome of 7 eucaryotes. Fifty-four of 71 translation-related genes were conserved, highlighting the importance of proteins in modern organisms. Translation initiation factors (KOG0343, KOG3271) and prolyl-tRNA synthetase (KOG4163) showed high conservation based on the distance value analysis. The genes of Caenorhabditis elegans appear to harbor high genetic variation because the genome showed the highest variation at 71 conserved proteins among 7 genomes. The 71 conserved genes will be valuable in basic and applied research, for example, targeting for antibiotic development.
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KEYWORD
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Conserved gene, genome, ortholog, Clusters of Orthologous Groups of proteins (COG), euKaryotic Orthologous Group (KOG)
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